Clustering of Nicotinic Acetylcholine Receptors: From the Neuromuscular Junction to Interneuronal Synapses
نویسندگان
چکیده
منابع مشابه
Regulation of acetylcholine release by presynaptic nicotinic receptors at developing neuromuscular synapses.
Autoregulation of synaptic transmission in the nervous system is one of the homeostatic processes by which the transmission can be regulated according to varied physiological conditions. The neuromuscular cocultures of Xenopus laevis embryos were used to investigate the role of presynaptic nicotinic receptors in the autoregulation of developing motoneurons. The bath application of 2 microM nico...
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The molecular mechanisms that regulate the organization and activity of the neuromuscular junction remain to be fully identified. Caveolae are invaginations of the plasma membrane. Caveolin-3 is the structural protein component of caveolae in muscle cells. We show that caveolin-3 is expressed at the neuromuscular junction, that it associates with the nicotinic acetylcholine receptor (nAChR), an...
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The majority of acetylcholine receptors (AChRs) at normally innervated neuromuscular junctions are stable, with a half-life averaging about 12 d in most rodent muscles. Following denervation, the AChRs turn over much more rapidly after a lag period. The mechanism by which motor nerves normally maintain stabilization of junctional AChRs is not yet known. In order to determine whether synaptic tr...
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The distribution and turnover rate of acetylcholine receptors labeled with 125I-alpha-bungarotoxin were examined in innervated mouse sternomastoid muscle by electron microscope autoradiography using the "mask" analysis procedure. We compared the total population of receptors with receptors newly inserted at the junction 2 d after inactivation with nonradioactive alpha-bungarotoxin, both at the ...
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ژورنال
عنوان ژورنال: Molecular Neurobiology
سال: 2002
ISSN: 0893-7648
DOI: 10.1385/mn:25:1:079